To determine the effectivity of working of oral midodrine tablet in preventing fall in Blood pressure after spinal anesthesia in all lower limb and below abdomen surgeries by giving the tablet before spinal anesthesia
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/07/055663
- Lead Sponsor
- Rakshitha R
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA grade 1
Patients undergoing lower abdomen and lower limb surgeries
Patients without local anesthesia toxicity
Exclusion Criteria
1. Patients with history of hypertension, cardiovascular disease, cerebrovascular disease, baseline SBP >140mm Hg before administration of drug
2. Patients with any contraindications to spinal anesthesia
3. History of coagulopathy, pheochromocytoma.
4. Patients on vasoconstrictors.
5. Pregnancy .
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the efficacy of preoperative oral midodrine in prevention of hypotension after spinal anesthesia in patients undergoing lower abdominal & lower limb surgeries.Timepoint: Hemodynamic variables comprising SBP,DBP,MAP and HR will be recorded at 2,5, 10, 15, 20, 25, 30, 45, and 60 minutes after spinal anesthesia, every 15 mins until the end of the surgery.
- Secondary Outcome Measures
Name Time Method To assess hemodynamic parameters like SBP,DBP, MAP, HR for 24 hours after administration of MIDODRINE. <br/ ><br>To asses the number of doses of mephentermine used.Timepoint: 12 hours