CTRI/2018/06/014499尚未招募Unknown
Comparison of dexmedetomidine and clonidine for attenuation of the sympathoadrenal responses to laryngoscopy and endotracheal intubation
Vardhman Mahavir Medical College and Safdarjung Hospital1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2018年6月20日最近更新:
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- To compare the hemodynamic responses (HR, NIBP) and SpO2 variations in response to laryngoscopy and endotracheal intubation using either intravenous dexmedetomidine (1mcg/kg) or clonidine (1mcg/kg)
研究概览
简要总结
-
To compare the hemodynamic responses (HR, NIBP) and SpO2 variations in response to laryngoscopy and endotracheal intubation using either intravenous dexmedetomidine (1mcg/kg) or clonidine (1mcg/kg)
-
To assess the level of sedation between the groups using Ramsay Sedation Score
HYPOTHESIS : Dexmedetomidine is better than clonidine, when administered as an infusion, prior to induction of general anaesthesia, in blunting the sympathoadrenal responses to both laryngoscopy and endotracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grades I and II, BMI less than or equal to 30 kg/m2.
排除标准
- •Difficult airway (Mallampati grades 3 & 4 )
- •Pregnant and nursing women
- •Patients who require emergency surgical interventions.
- •Patients with hemodynamic instability or having cardiac, hepatic, renal, endocrine, hypertensive disorders and on medications like beta-blockers, digitalis, anti-psychotics, anxiolytics, sedatives or patients allergic to study medications.
结局指标
主要结局
To compare the hemodynamic responses (HR, NIBP) and SpO2 variations in response to laryngoscopy and endotracheal intubation using either intravenous dexmedetomidine (1mcg/kg) or clonidine (1mcg/kg)
时间窗: At the time of pre-intubation and post-intubation
次要结局
- To assess the level of sedation between the groups using Ramsay Sedation Score.(After infusion of test drug)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
4 期
effect of dexmedetomidine during general surgeryCTRI/2013/07/003820Dept of Anaesthesiology100
已完成
4 期
Dexmedetomidine for Attenuation of Pressor ResponsePressor ResponseNCT06592027Theodor Bilharz Research Institute60
已完成
不适用
Nerve Block Vs Sedation Infusion for Awake Fiberoptic Intubation.Superior Laryngeal Nerve BlockSedationDexmedetomidineAwake Fiberoptic IntubationHemimandibulectomyAnticipated Difficult AirwayNCT06651905Cairo University80
已完成
4 期
Attenuation Of Hemodynamic Response To Laryngoscopy. Role Of Dexmedetomidine. A Dose Finding StudyHemodynamic InstabilityTracheal IntubationDexmedetomidineNCT05909215Sindh Institute of Urology and Transplantation105
招募中
4 期
Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic CholecystectomyHemodynamic ResponsesLaparoscopic CholecystectomyDexmedetomidineLidocainePropofolNCT05937282Menoufia University80