Comparison of two different drugs for attenuation of the hemodynamic responses to laryngoscopy and endotracheal intubation

Not Applicable

Not yet recruiting

• Conditions: Patient age 18-60 years of either sex, of ASA grades I and II having BMI less than or equal to 30 kg/m2

• Registration Number: CTRI/2018/06/014499
• Lead Sponsor: Vardhman Mahavir Medical College and Safdarjung Hospital

Brief Summary

1. To compare the hemodynamic responses (HR, NIBP) and SpO2 variations in response to laryngoscopy and endotracheal intubation using either intravenous dexmedetomidine (1mcg/kg) or clonidine (1mcg/kg)

2. To assess the level of sedation between the groups using Ramsay Sedation Score

HYPOTHESIS : Dexmedetomidine is better than clonidine, when administered as an infusion, prior to induction of general anaesthesia, in blunting the sympathoadrenal responses to both laryngoscopy and endotracheal intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-20
• Last Update Posted: 2018-08-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

ASA grades I and II, BMI less than or equal to 30 kg/m2.

Exclusion Criteria

• Difficult airway (Mallampati grades 3 & 4 ) 2.
• Pregnant and nursing women 3.
• Patients who require emergency surgical interventions.
• Patients with hemodynamic instability or having cardiac, hepatic, renal, endocrine, hypertensive disorders and on medications like beta-blockers, digitalis, anti-psychotics, anxiolytics, sedatives or patients allergic to study medications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the hemodynamic responses (HR, NIBP) and SpO2 variations in response to laryngoscopy and endotracheal intubation using either intravenous dexmedetomidine (1mcg/kg) or clonidine (1mcg/kg)	At the time of pre-intubation and post-intubation

Secondary Outcome Measures

Name	Time	Method
To assess the level of sedation between the groups using Ramsay Sedation Score.	After infusion of test drug

Trial Locations

Locations (1)

Vardhman Mahavir Medical College and Safdarjung Hospital; 🇮🇳 South, DELHI, India

Vardhman Mahavir Medical College and Safdarjung Hospital

🇮🇳South, DELHI, India

Dr Mohit Gupta

Principal investigator

9999407977

mohit.0802009@gmail.com