The effects of aspirin on the platelet function of healty volunteers and of patients with occlusive arterial vascular disease.
- Conditions
- aspirin non-respondersaspirin resistance1000796310003216
- Registration Number
- NL-OMON31793
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
population A: healthy, BMI <27.5, non smoker.
Population B1: stroke in medical history (large vessel disease) between 01-07-01 and 01-07-06. No- recurrent stroke. Therapie with carbasalate calcium 100mg daily.
Population B2: recurrent stroke in medical history despite therapy with carbasalate calcium 100mg daily. First stroke between 01-07-01 and 01-07-06. last stoke > 3 months ago.
Population A: any contra-indication for carbasalate calcium. The use of NSAIDs. Cardiovascular disease, Diabetes Mellitus. recent operation (3 months)
Population B: therapy with clopidogrel, NSAIDs, oral anticoagulation therapy. Known malignancy, operation < 3 months ago. Cardiovascular event < 3 months ago. Known hematologic disease. Thrombocytopenia(< 100000/mm3), thrombocytosis (> 400 000/mm3), anemia, polycytemia (Ht>50%)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method