Comparative study on effectiveness of inhaler treatment for elderly patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS)

Asan Medical Center0 个研究点目标入组 300 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

暂无简介。

•1)ACOS definition - any of following 3 criteria
•(1) positive response bronchodilator: > 200mL forced expiratory volume in 1s (FEV1) and > 12% baseline
•(2) positive methacholine or mannitol provocation test
•(3) increase in FEV1 by > 12% and 200 mL from baseline after 4weeks of treatment
•and satisfied pre-bronchodilator FEV1/FVC ratio < 0.7 at the initial time and continuing after at least 3 months follow-up
•2) controlled patients with ICS+LABA treatment
•3) patients over 19 years of age
•4) 30 = FEV1 (%) < 80
•5) acute exacerbation history past 1-year
•6) patients agreed to participate in clinical trials

•1) severe benign prostste hypertrophy (BPH)
•End-stage renal disease, chronic renal failure
•2) heart failure or previous history of myocardial infarction during 1-year
•3) active infection such as pneumonia, pulmonary tuberculosis, fungal infection
•4) moderate to severe bronchiectasis
•5) Tb destroyed lung
•6) acute exacervation of Visit 1
•7) pregnancy and breast-feeding
•8) using the systemic steroid due to other disease
•9) receipt of immunotherapy
•10) other patients judged to be inappropriate by clinician

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