Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study

Not Applicable

• Conditions: Transcutaneous Nerve Stimulation
• Interventions: Device: "Enraf-Nonius" Muscle stimulator

• Registration Number: NCT02115841
• Lead Sponsor: Chang Gung University

Brief Summary

Noninvasive brain stimulation was recently gradually be emphasized. The electrical current applied on scalp can effective modulate cortical excitability. Forms of Stimulation included transcranial direct current stimulation(tDCS) and transcranial alternating stimulation(tACS). tDCS had been proved the effect of cortical excitability modulation. The polarization effect of direct current stimulation can modulation specific brain area and enhance motor performance. tACS was still controversial about the effect on cortical excitability. Previous study show that the frequency dependent excitatory or inhibitory effect on cortex. The possible mechanism was to affect brain oscillation status by provided different frequency of stimulation. Transcutaneous nerve stimulation (TENS) was common used on management of chronic pain. Peripheral nerve stimulation can enhance pain or sensory evoked potential was noted. Effect of low frequency TENS on central nervous is unknown.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08
• Study First Submitted: 2014-03-27
• Status Verified: 2014-04
• Study First Submitted QC: 2014-04-14
• Last Update Submitted: 2014-04-14
• Study First Posted: 2014-04-16
• Last Update Posted: 2014-04-16
• Primary Completion: 2014-07
• Study Completion: 2014-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Health Adult

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
E1	"Enraf-Nonius" Muscle stimulator	Experiment 1 will measure the cortical excitability change after TENS intervention.
E2	"Enraf-Nonius" Muscle stimulator	Experiment 2 will measures implicit sequential motor task performance and cortical hemodynamic response using near infrared spectroscopy (NIRS) during motor execution. Cortical excitability will also be measured contemporary

Primary Outcome Measures

Name	Time	Method
Motor evoked potential	Baseline,0 minute,30 minutes,60 minutes.	Use single-pulse TMS to assess Motor evoked potential change.
Implicit sequential motor task performance	Baseline,in experiment,0 minute,30 minutes,60 minutes.	Change of Measure of Learning curve.
Intracortical inhibition & Intracortical facilitation	Baseline,0 minute,30 minutes,60 minutes.	Use paired-pulse TMS to record pre-test and post-test change.
Blood oxygen dependent level	Baseline,in experiment,0 minute,30 minutes,60 minutes.	Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change

Trial Locations

Locations (1)

Chang Gung University; 🇨🇳 Taoyuan, Taiwan