A study of correlation between differences in ventricular activation and degree of response to left bundle branch area pacing and biventricular pacing cardiac resynchronization therapy

Not Applicable

Recruiting

• Conditions: Cardiovascular - Other cardiovascular diseases; Heart failure

• Registration Number: ACTRN12624000428561
• Lead Sponsor: Dr. Rajeev Kumar Pathak

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-08
• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1.Patients with LBBB, QRS 130 ms or greater and HF who had LVEF 35% or less at baseline.
2.Received either BiV or LBBAP CRT.
3.Super-responders: Those who demonstrated 20% or more improvement in LVEF at 12 months post-procedure.
4.Non-responders: Those who demonstrated less than 10% in LVEF at 12 months post-procedure.

Exclusion Criteria

1.Patients with dyssynchrony other than LBBB and/or QRS <130 ms at baseline
2.Patients with LVEF >35% at baseline
3.Patients with intermediate (10-19%) improvement in LVEF at 12 months post-procedure.
4.Refuse to/unable to give consent.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eDYS – time difference between the earliest and latest activation site [Time of latest activated site - earliest activated site on noninvasive cardiac activation map generated by Cardioinsight system which collects surface ECG signals.<br>When available, earliest and latest activated sites will be assessed from endocardial map as well. At the time of cardiac mapping]

Secondary Outcome Measures

Name	Time	Method
Global right/left ventricular electrical synchrony: the difference between mean RV and LV activation times [Total time for right and left ventricular activation will be calculated and difference will be derived from noninvasive cardiac activation map generated by Cardioinsight system which collects surface ECG signals.<br>The same will be calculated from endocardial map when available. At the time of cardiac mapping];Global biventricular total activation time[Total time taken by both ventricles for activation from noninvasive cardiac activation map generated by Cardioinsight system which collects surface ECG signals.<br>The same will be calculated from endocardial map when available. At the time of cardiac mapping];Global LV activation time[Total time taken by left ventricle for activation from noninvasive cardiac activation map generated by Cardioinsight system which collects surface ECG signals.<br>The same will be calculated from endocardial map when available. At the time of cardiac mapping]