A comparative study to evaluate the effect of two different doses (intravenously administered bolus vs iv bolus plus infusion) of tranexamic acid in reducing intraoperative blood loss in patients undergoing pancreaticobiliary surgeries.
Not Applicable
Completed
- Conditions
- Health Condition 1: K80-K87- Disorders of gallbladder, biliary tract and pancreas
- Registration Number
- CTRI/2022/10/046692
- Lead Sponsor
- All India Institute of Medical Sciences New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 62
Inclusion Criteria
ASA I and II patients undergoing open pancreaticobiliary surgeries( including surgeries for tumors, obstruction, injusries of the pancreas and bile ducts eg. Whipple surgery, pancreatectomy, extended cholecystectomy)
Exclusion Criteria
patients with known coagulopathy or thrombocytopenias, patients with history of stroke, , CAD or PVD , CKD or CLD, patients with history of DVT or thromboembolism, pregnant or lactating women, patients with preoperative Hb less than 10g/dl, patients undergoing major hepatic surgeries and patients having indwelling catheters( chemoports)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to compare intraoperative blood loss between two groups( tranexamic acid bolus vs tranexamic acid bolus plus infusion)Timepoint: intraoperative blood loss will be assesed and patients will be followed up 12 hrly for the first 24 hrs then daily during their hospital stay
- Secondary Outcome Measures
Name Time Method number of units of intraoperative PRBC transfused, percentage change in hematocrit( preoperative vs postoperative), duration of hospital stay, 28 days mortalityTimepoint: patients will be followed up 12 hrly for the first 24 hrs then daily during their hospital stay