Serum Magnesium and Nit Vitamin D is Associated With Better QoL in COPD: A Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 143
- 试验地点
- 1
- 主要终点
- Serum Vitamin D
研究概览
简要总结
The aim of this study was to investigate the associations between serum concentrations of vitamin D, Magnesium and Calcium in Chronic obstructive pulmonary disease patients and the potential impact of these parameters on lung function and quality of life.
详细描述
Attention is enhancing worldwide on the increasing tendency of insufficient 25-hydroxyvitamin D serum levels. New insights into the role of vitamin D and distribution of its receptors in the human body have been revealed. Presumably, this entails implications concerning disease and treatment that go far beyond the well-known field of bone-metabolism.
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), and reductions in vitamin D serum levels have formerly been perceived as a consequence rather than a cause of COPD.
Yet, there is a lack of consensus concerning the role of vitamin D on the decreasing lung function in COPD.
Some trials have revealed a high degree of co-variation between the grade of airway obstruction, intake of vitamin D and reduction of serum-vitamin D. Other claim that vitamin D appears to be capable of inhibiting pulmonary inflammatory responses.
Vitamin D interacts with calcium and magnesium and this subtle balance might be highly relevant in the progression of inflammatory diseases like COPD. Presumably, Mg inhibits contraction and relaxes smooth muscles in airways due to blocking of calcium-ion-flux across the cell membrane.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COPD-patients
- •Unchanged medical treatment for COPD for the last 4 weeks
- •Outpatients
- •adults over 40 years
排除标准
- •COPD exacerbation, which resulted in hospitalization and/or modification of medical treatment within 4 weeks
- •Patients with other lung diseases, such as active tuberculosis, lung cancer, sarcoidosis and pulmonary fibrosis
- •diseases affecting vitamin D and/or calcium and/or magnesium distribution
- •Previous lung resection
- •Treatment with systemic steroids
- •Known addiction problems with alcohol and/or drugs
结局指标
主要结局
Serum Vitamin D
时间窗: one year
vitamin D measured by p-25-hydroxy-vitamin D2 + D3, in mmol/L
次要结局
- Lung Function Test(one year)
- Serum Magnesium(One year)
- Serum Calcium(One year)
- Quality of Life(One year)