Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- To investigate whether bosentan compared to placebo reduces hypoxia-induced increase in pulmonary artery pressure in healthy subjects and in subjects with past history of high-altitude pulmonary oedema
研究概览
简要总结
Excessive rise in pulmonary artery pressure induced by low oxygen tension (hypoxia) is one of the factors implicated in high-altitude pulmonary oedema. Plasma ET1 increases in subjects exposed to high altitude and is correlated to pulmonary artery pressure.
The aim of the study is to investigate whether blockade of ET1 receptors would reduce the acute rise in systolic pulmonary artery pressure induced by hypoxia.
详细描述
Patients will be examined on a variable load supine bicycle ergometer. The exercise table will be tilted laterally by 20 to 30 degrees to the left. PASP will be assessed using Doppler echocardiography at rest and during during supine bicycle exercise in NORMOXIA and hypoxia. Exposure to normobaric hypoxia will be performed by breathing a hypoxic gas mixture at sea level during 90 minutes (12,3 % O2 + 87.7 % N2) reproducing conditions at 4300 m altitude. Exercise will be started at an initial workload of 40 watts and increased by 10 watts every minute to reach a workload level defined by a heart rate (HR) corresponding to 50% of the estimated maximal aerobic power
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •20 non smoker healthy volunteers : 10 resistant to high-altitude pulmonary oedema and 10 susceptible subjects, without history of cardiac or pulmonary disease or asthma, after a complete clinical examination and safety laboratory measurements prior to randomization, and after giving informed written consent.
排除标准
- •antecedent of lung disease notably with asthmatic antecedent or HTAP
- •antecedent of heart disease
- •female genital organ
- •systolic blood pressure < 85 mmHg or > 160 mmHg after 5 minutes of lengthened rest.
- •sentimentality in a medicine, in particular in a bosentan or in one of the excipients of the tablet.
- •hepatic incapacity moderated to severe correspondent in the class B or C of the classification of Child-Pugh (cf Pharmacokinetics) Rate serous hepatic aminotransferases, aspartate aminotransferases( ASAT) and\or alanine aminotransférases ( ALAT), superior to 3 times the superior limit of the normal before the started of the treatment.
- •pointed or chronic systematic diseases.
- •presence of antibody anti-HIV, of anti-HVC antibody, antigens Hbs and\or antibody anti-Hbc. - active addiction to smoking.
- •alcohol abuse and of toxins.
- •Taking of concomitant medicines except those allowed the chapter concomitant treatments.
- •signs, symptoms or values of the biological examinations situated except the clinically acceptable values for healthy subjects with or without antecedent of OPHA.
- •common(current) ingestion of excessive quantities of tea, coffee(cafe), chocolate and\or drinks containing some caffeine (> 5 cups / day, is approximately 500 mg of caffeine a day).
- •consumption of juice of grapefruit and\or herb tea on base of St.
- •John's wort
- •Don of blood in 3 months preceding the study.
- •Persons in period of exclusion on the national file of the persons lending itself to the biomedical search(research) without direct individual profit.
- •refusal or linguistic or psychic incapacity to sign the lit(enlightened) assent.
- •subject which can not submit itself to the constraints of the protocol (for example, not cooperative, incapable to go(surrender) to the visits of follow-up and probably incapable to finish the study
研究组 & 干预措施
1
Experimental and Placebo Comparator administered in random order during to successive experimental phase
干预措施: Bosentan (Drug)
2
Experimental and Placebo Comparator administered in random order during to successive experimental phase
干预措施: Bosentam TRACLEER (Drug)
结局指标
主要结局
To investigate whether bosentan compared to placebo reduces hypoxia-induced increase in pulmonary artery pressure in healthy subjects and in subjects with past history of high-altitude pulmonary oedema
时间窗: during the study
次要结局
- To compare(during the study)
- pulmonary artery pressure response to exercise,(during the study)
- and to assess the global safety(during the study)
- exercise capacity,(during the study)
- oxygen desaturation,(during the study)