Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension
- Conditions
- Pulmonary Hypertension
- Registration Number
- NCT03195959
- Lead Sponsor
- University of Zurich
- Brief Summary
Pulmonary Hypertension (PH) is a severe disease with a bad prognosis. However, thanks to extensive research in this field, there are more and better treatment options that allow patients to participate in recreational activities at moderate altitude or bring up the question of air-travel.
Still very few is known about the effects hypoxic conditions have on PH patients. The aim of this study is to investigate the effects of hypoxia in comparison to normoxia and hyperoxia on pulmonary hemodynamics in patients with pulmonary hypertension during routine right heart catheterisation. We aim to get insight into the pathophysiology of pulmonary hemodynamics under hypoxic conditions in comparison to normoxia and hyperoxia in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension compared with control patients, that are scheduled for right heart catheterisation due to dyspnea but have no PH.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
- clinically indicated right heart catheterisation
- diagnosis of pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension or control without pulmonary hypertension
- hemodynamically unstable
- partial pressure of Oxygen < 7.3kPa
- no informed consent
- pulmonary hypertension due to left heart disease, chronic lung disease or miscellaneous (Groups II, III and V) according to Galié ERJ 2015
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of pulmonary vascular resistance during hypoxia in comparison to normoxia and hyperoxia Day 1
- Secondary Outcome Measures
Name Time Method change of the partial pressure of oxygen under hyperoxia in comparison to normoxia and hyperoxia Day 1 change of the partial pressure of carbon dioxide under hyperoxia in comparison to normoxia and hyperoxia Day 1 change of mean pulmonary artery pressure under hyperoxia in comparison to normoxia and hyperoxia Day 1 change of the cardiac output under hyperoxia in comparison to normoxia and hyperoxia Day 1
Trial Locations
- Locations (1)
UniversityHospital Zurich, Department of Pulmonology
🇨🇭Zürich, Switzerland
UniversityHospital Zurich, Department of Pulmonology🇨🇭Zürich, Switzerland