COMPARISON OF REVERSIBILITY OF SUGAMMADEX AND NEOSTIGMINE TO VECURONIUM USED AS MUSCLE RELAXANT UNDER GENERAL ANAESTHESIA

Sugammadex is a modified γ-cyclodextrin designed to reverse the effects of the steroidal neuromuscular blocking agents (NMBAs) rocuronium and vecuronium by encapsulation with no effect on cholinergic transmission.In contrast to neostigmine, sugammadex rapidly and effectively re- verses moderate and deep levels of  vecuronium-in- duced neuromuscular blockade (NMB) , and is also effective for immediate reversal of blockade. We wanted to compare between reversibility of sugammadex and neostigmine in prolonged surgeries . Aim is to compare the efficacy of sugammadex with neostigmine for reversal of the effects of  vecuronium as muscle relaxant. Objective is to

compare the reversibility of neostigmine with sugammadex using TOF

To compare :

1. Time required for complete reversal .

2. Any residual paralysis / block with standard doses and requirement of added doses.

3. Side effect if any in post operative period (muscle pain , recurarization / apnea).

This study includes patients classified Under American Society of Anaesthesiologists Physical status I,II&III planned for surgery under general anesthesia.

Group A will receive neostigmine 0.05 mg/ kg . If TOF not till T4 then dose converted to 1 mg/ kg.

Group B will receive sugammadex 2mg/ kg. If in deeper plain of anaesthesia then 4 mg/ kg.

The onset, duration and side effects of post operative analgesia will be recorded and compared