Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Postoperative Cognitive Dysfunction
- 发起方
- Xuzhou Medical University
- 入组人数
- 215
- 试验地点
- 1
- 主要终点
- the neuropsychological tests
- 状态
- 已完成
- 最后更新
- 6年前
概览
简要总结
To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.
研究者
Han Yuan
Doctor-in-charge of Anesthetist
Xuzhou Medical University
入排标准
入选标准
- •Non-cardiac surgery patients;
- •Age is greater than or equal to 60 years old;
- •Han Nationality, mother tongue is chinese;
- •The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
- •The Geriatric Depression Scale (GDS) grade 1 or 2;
- •The important function without serious heart, brain, liver, kidney, lung and other organs;
- •The ASA class I or II;
- •The people signed informed consent.
排除标准
- •The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.;
- •Had severe head and face disease, trauma history or history of surgery;
- •The serious body disease and tobacco, wine and other substance abuse history;
- •The presence of malignant tumor with shorter survival disease.
结局指标
主要结局
the neuropsychological tests
时间窗: within the first 7 days (plus or minus 2 days) after surgery
the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement,the Test Finger Tapping Test, the Word Fluency Test and the Building Block Test.
Mini-Mental score examination [MMSE]
时间窗: within the first 7 days (plus or minus 2 days) after surgery
Mini-Mental score examination \[MMSE\] used for screening of dementia