Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients

Not Applicable

Completed

• Conditions: Alpha-1-antitrypsin-deficiency; Chronic Obstructive Pulmonary Disease
• Interventions: Procedure: exercise training

• Registration Number: NCT01380626
• Lead Sponsor: Schön Klinik Berchtesgadener Land

Brief Summary

Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02
• Study First Submitted: 2011-06-22
• Study First Submitted QC: 2011-06-23
• Study First Posted: 2011-06-27
• Primary Completion: 2013-03
• Study Completion: 2013-04
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-16
• Last Update Posted: 2013-12-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• COPD
• Alpha-1-Antitrypsine-deficiency, phenotype: ZZ
• FEV1%pred. <50

Exclusion Criteria

• acute exacerbation
• exacerbation in the last 4 weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
exercise training	exercise training	-

Primary Outcome Measures

Name	Time	Method
aerobic and anaerobic enzymes	day 2 and 23	changes in quantity of enzymes from baseline to day 23

Secondary Outcome Measures

Name	Time	Method
maximal exercise capacity in incremental cycling test	day 2 and 23	Change in max. exercise capacity from baseline to day 23
6-minute-walking distance	day 3 and 24	change in 6-minute-walking distance from baseline to day 24

Trial Locations

Locations (1)

Klinikum Berchtesgadener Land; 🇩🇪 Berchtesgaden, Germany