Evolution of DMDD Children and Adolescent

Recruiting

• Conditions: Disruptive Mood Dysregulation Disorder; Prognosis Factors; Suicidal Behaviors; Actigraphy

• Registration Number: NCT04820946
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Little is known about the natural course and prognosis factors of inpatients and outpatients with Disruptive Mood Dysregulation Disorder (DMDD). The investigators conducted a cross-sectional study to determine the evolution of a sample of DMDD patients referred to the hospital for suicidal behaviors between 2013 and 2018 in terms of diagnostic stability, psychiatric comorbidity, and psychosocial factors. A group of patients with various episodic mood disturbances was used as a clinical case control group.

In addition to change in DMDD symptoms across time, the investigators examined the onset and persistence of psychiatric comorbidity using the KIDDIE-SADS PL and suicidal behaviors using the Colombia Suicidality Severity Rating Scale. The investigators also examined the persistence of depressive symptoms using the Beck Depression Inventory (BDI-II), the persistence of emotional lability (Affective Lability Scale-18), borderline traits (Abbreviated Diagnostic of Inventory Borderline). Socio-demographic, clinical features and actigraphy-measured sleep characteristics determined between 2013 and 2018 were used to predict the evolution of the DMDD patients and the clinical control group.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-24
• Study First Submitted: 2021-03-25
• Study First Submitted QC: 2021-03-26
• Study First Posted: 2021-03-29
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-11
• Last Update Posted: 2023-04-12
• Primary Completion: 2024-03
• Study Completion: 2024-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• Boys and girls between 10 and 25-year-old
• patients who had been referred to the university hospital of Amiens for suicidal behaviors between 2013 and 2018
• patients who participated to the study "Clinical and actigraphy-measured profiles of inpatient youths with suicidal behavior: exploration of the severe mood dysregulation"

Exclusion Criteria

• No affiliation to a social security service
• Persons deprived of their liberty as stipulated in article L.1121-6 of the Public Health Code

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnostic evolution toward an other psychiatric disorder.	one day	The evolution toward another psychiatric disorder would be examined using the semi-structured interview KIDDIE-SADS and the Ab-DIB to examine borderline traits.; The K-SADS is a semi-structured interview to measure current and past symptoms of mood, anxiety, psychotic, and disruptive behavior disorders in children ages 6-18 years old.; (Ab-DIB) as a screening measure of borderline psychopathology in an adolescent clinical population.
persistence of a full-blown DMDD diagnostic	one day	The persistence of a full-blown DMDD diagnostic would be defined using the DSM-5 criteria. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) is the 2013 update to the Diagnostic and Statistical Manual of Mental Disorders, the taxonomic and diagnostic tool published by the American Psychiatric Association.

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France