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临床试验/CTRI/2025/11/096969
CTRI/2025/11/096969尚未招募不适用

Carotid Artery Corrected Flow Time and Respiratory Variation of Blood Flow Peak Velocity for Prediction of Hypotension after Induction of General Anesthesia in Elderly Patients Undergoing Elective Open Abdominal Surgery: A Prospective Observational Study.

All India Institute of Medical SciencesPatna1 个研究点 分布在 1 个国家目标入组 88 人开始时间: 2025年11月20日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
88
试验地点
1
主要终点
Ability of carotid artery corrected flow time and respiratory variation of carotid blood flow peak velocity measured by Doppler ultrasound to predict the occurrence of hypotension following induction of general anesthesia in elderly patients undergoing laparotomy.

研究概览

简要总结

Elderly patients undergoing major abdominal surgeries such as laparotomy are at a higher risk of developing hypotension following induction of general anesthesia due to age-related cardiovascular changes and altered autonomic regulation. Early prediction of post-induction hypotension allows timely preventive measures, such as optimized fluid therapy and vasopressor support.

This prospective observational study aims to evaluate whether noninvasive Doppler-derived parameter such as carotid artery corrected flow time and respiratory variation of blood flow peak velocity can predict the occurrence of hypotension after induction of general anesthesia in elderly patients undergoing elective laparotomy.

Pre-induction CFT and variation in  Vpeak will be measured using carotid Doppler ultrasound, and hemodynamic parameters will be recorded immediately after induction and for 5 minutes thereafter. The correlation of these ultrasound indices with hypotension will be analyzed, along with their sensitivity, specificity, and accuracy compared to conventional predictors such as age, comorbidities, and baseline blood pressure.

Findings from this study may help identify simple, noninvasive, bedside tools to anticipate and prevent anesthesia-induced hypotension in high-risk elderly patients.

研究设计

研究类型
Observational

入排标准

年龄范围
60.00 Year(s) 至 99.00 Year(s)(—)
性别
All

入选标准

  • Age greater than or equal to 60 years ASA physical status I to III Patients undergoing elective laparotomy.

排除标准

  • Severe cardiovascular or respiratory diseases Autonomic dysfunction Uncontrollable BP with multiple drugs emergency procedure BMI greater than 30 Known comorbidity influencing hemodynamics.

结局指标

主要结局

Ability of carotid artery corrected flow time and respiratory variation of carotid blood flow peak velocity measured by Doppler ultrasound to predict the occurrence of hypotension following induction of general anesthesia in elderly patients undergoing laparotomy.

时间窗: pre-induction and at 1,3 and 5 minutes post-induction.

次要结局

  • Accuracy and reliability of CFT in predicting intraoperative hypotension(5 minutes)

研究者

发起方
All India Institute of Medical SciencesPatna
申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Dr Sreehari S

AIIMS PATNA

研究点 (1)

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