Impact of amyloid beta retention and brain derived neurotrophic factor Val66Met polymorphism on change in cognitive function and intrinsic functional/structural brain network connectivity after transcranial direct current stimulation in mild cognitive impairment patients: parallel designed, patient-assessor blind, investigator initiated trials

The Catholic University of Korea, Yeouido St. Mary's Hospital0 个研究点目标入组 90 人开始时间: 待定最近更新: 2021年4月22日

适应症

试验速览

暂无简介。

•patients with MCI met Peterson’s criteria of (1) memory complaint, corroborated by an informant, (2) objective memory impairment for age, level of education, and sex; (3) essentially preserved general cognitive function; (4) mostly intact functional activities; and (5) no dementia. All patients with MCI had an overall Clinical Dementia Rating of 0.5. Objective memory impairment was defined as a performance score of 1.5 standard deviations (SDs) below the respective age-, education-, and sex-specific normative means on at least one of the four episodic memory tests included in the CERAD-K, that is, WLM, WLR, WLRc, and CR.

•We excluded participants with any history of alcoholism, drug abuse, head trauma, or psychiatric disorders, those taking any psychotropic medications (e.g., cholinesterase inhibitors, antidepressants, benzodiazepines, and antipsychotics), those with multiple vascular risk factors, and those with extensive cerebrovascular disease.

发起方