Impact of dementia risk factors on change in cognitive function and brain structural/functional parameters after brain stimulation in high-risk group of dementia

Not Applicable

Recruiting

• Conditions: Diseases of the nervous system

• Registration Number: KCT0006020
• Lead Sponsor: The Catholic University of Korea, Yeouido St. Mary's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 April 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

patients with MCI met Peterson’s criteria of (1) memory complaint, corroborated by an informant, (2) objective memory impairment for age, level of education, and sex; (3) essentially preserved general cognitive function; (4) mostly intact functional activities; and (5) no dementia. All patients with MCI had an overall Clinical Dementia Rating of 0.5. Objective memory impairment was defined as a performance score of 1.5 standard deviations (SDs) below the respective age-, education-, and sex-specific normative means on at least one of the four episodic memory tests included in the CERAD-K, that is, WLM, WLR, WLRc, and CR.

Exclusion Criteria

We excluded participants with any history of alcoholism, drug abuse, head trauma, or psychiatric disorders, those taking any psychotropic medications (e.g., cholinesterase inhibitors, antidepressants, benzodiazepines, and antipsychotics), those with multiple vascular risk factors, and those with extensive cerebrovascular disease.

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cognitive function scores;parameters values of brain magnetic resonance imaging

Secondary Outcome Measures

Name	Time	Method
cognitive function subdomains scores;functional segregation and integration parameters of brain magnetic resonance imaging