Amyloid deposition and cognitive function in Obstructive Sleep Apnoea

Not Applicable

• Conditions: Obstructive Sleep Apnoea; Respiratory - Sleep apnoea

• Registration Number: ACTRN12618000618257
• Lead Sponsor: Institute for Breathing and Sleep

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-20
• Study Completion: 2019-12-18
• Last Update Posted: 10 May 2021

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

Aged 50-75 years; OSA diagnosis (AHI>15 events/hr); are OSA treatment-naïve; sufficient English to undertake cognitive testing; able to provide informed consent.

Healthy controls will be age- and gender-matched to the OSA group. The will be required to have sufficient English to undertake cognitive testing; able to provide informed consent; must have no sleep disorder (AHI <5 events/hr).

Exclusion Criteria

Active medical or psychiatric condition that may interfere with study procedures; or a previous diagnosis of dementia; pregnancy.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Degree of brain beta-amyloid burden as assessed by Positron Emission Tomography imaging. [Baseline]