Amyloid accumulation in healthy elderly

• Conditions: Cognitively healthy elderly, aged 60-100 years old.; Therapeutic area: Diseases [C] - Nervous System Diseases [C10]

• Registration Number: EUCTR2014-000219-15-NL
• Lead Sponsor: VU Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08-28
• Last Update Posted: 8 December 2014

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

- Age 60-100 years
- Monozygotic twin
- Telephone Interview for Cognitive Status modified (TICS­m) >22
- Geriatric Depression Scale (GDS) (15 item) <11
- Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) 10 word list immediate and delayed recall (> -1.5 SD of age adjusted normative data)
- Clinical Dementia Rating (CDR) scale of 0 with a score on the memory subdomain of 0
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 40
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 260

Exclusion Criteria

- clinical diagnosis of probable Alzheimer's disease or mild cognitive impairment
- neurological problems like Parkinson's disease, Huntington disease, severe head trauma, braintumour, stroke with physical impairment, epilepsy currently using antiepileptic drugs, braininfection
- known uncontrolled diabetes, thyroid disease, vitamin B12 deficiency
- psychiatric disorder like psychosis or schizophrenia

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified