Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment
Not Applicable
- Conditions
- Stroke
- Registration Number
- NCT00530478
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
The purpose of this study is to demonstrate the efficacy and safety of donepezil on the recovery of cognitive function in patients with stroke and to delineate the neurophysiologic mechanisms of the therapeutic effect of donepezil on the recovery of cognitive network using functional neuroimaging technique.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Ischemic stroke in the territory of right or left middle cerebral artery
- Post-onset duration of the recent-onset stroke is over 3 months
- Cognitive deficit ranged from 10 to 26 by minimal mental status examination (MMSE) score
- Disturbance in activities of daily living (ADL) ranged 0.5 ~ 2.0 by clinical dementia rating (CDR) scale
Exclusion Criteria
- Severe internal carotid artery stenosis on the lesion side
- Cardiac pacemaker or intracranial metal insertion
- Post-stroke seizure disorder or any evidence of epileptic spikes on electroencephalography (EEG)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of