Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

Phase 2

Recruiting

• Conditions: Alcohol Use Disorder

• Registration Number: NCT05042102
• Lead Sponsor: VA Connecticut Healthcare System

Brief Summary

The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-09-03
• Study First Submitted QC: 2021-09-03
• Study First Posted: 2021-09-13
• Study Start: 2022-08-08
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-07
• Last Update Posted: 2023-11-08
• Primary Completion: 2026-05-31
• Study Completion: 2026-05-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Heavy drinking days	13 weeks of active intervention	Heavy drinking days as measured by weekly Time Line Follow Back (TLFB)

Secondary Outcome Measures

Name	Time	Method
Global neurocognitive functioning	At 7 weeks and at 13 weeks	Global neurocognitive functioning on a global index of neurocognitive function

Trial Locations

Locations (1)

VA Connecticut Healthcare System; 🇺🇸 West Haven, Connecticut, United States