Measurement of blood flow in internal carotid artery (supplying blood to head and neck region) by sonography in patients undergoing gallbladder removal by laparoscopy.

Completed

Brief Summary: This study is aimed studying blood flow changes in Internal Carotid Artery in patients undergoing laparoscopic cholecystectomy under general anaesthesia. Diameter and velocity of Internal carotid artery will be calculated using ultrasonography at following time points - before induction of anaesthesia, just after induction, after creation of pneumoperitoneum and after head up tilt, along with other vital parameters like blood pressure, heart rate, oxygen saturation and end tidal carbon dioxide. Significant physiological changes can occur during1. Induction of anaesthesia2. Creation of pneumoperitoneum 3. Head up tilt ( reverse Trendelenburg position ) the proposed study further add to our knowledge how the internal carotid artery blood flow and cardiac output is affected during different stages of laparoscopic cholecystectomy under general anaesthesia.

Recruitment & Eligibility

Inclusion Criteria

consenting patients of either sex undergoing elective laparoscopic cholecystectomy under general anaesthesia.
Age 18-60 years 3.
Non obese patients (BMI equal to or less than 32kg/m2) 4.
Patients belonging to physical status ASA grade I/II.

Exclusion Criteria

patients falling in criteria but not giving consent to participate in the study.
ASAngrade III/IV/V 3.
patients with hyperlipidaemia, known coronary artery disease, hyertension, cerebrovascular disease, diabetes mellitus, patients on beta blockers or on statin therapy.

Primary Outcome Measures

Name	Time	Method
To derive and study changes in internal carotid artery blood flow ultrasonographically in patients	1- Awake - just before induction of anaesthesia. \| 2- Two minutes after induction of anaesthesia, \| 3- Two minutes after creation of pneumoperitoneum and \| 4- Two minutes after providing head up tilt.
undergoing elective laparoscopic cholecystectomy under general anaesthesia in terms of internal	1- Awake - just before induction of anaesthesia. \| 2- Two minutes after induction of anaesthesia, \| 3- Two minutes after creation of pneumoperitoneum and \| 4- Two minutes after providing head up tilt.
carotid artery diameter, internal carotid artery velocity and beat volume	1- Awake - just before induction of anaesthesia. \| 2- Two minutes after induction of anaesthesia, \| 3- Two minutes after creation of pneumoperitoneum and \| 4- Two minutes after providing head up tilt.

Secondary Outcome Measures

Name	Time	Method
To derive and calculate cardiac output by Liljestrand and Zander formula	1- Awake - just before induction of anaesthesia.

Locations (1): Mahatma Gandhi Medical College and Hospital
🇮🇳
Jaipur, RAJASTHAN, India
Mahatma Gandhi Medical College and Hospital
🇮🇳Jaipur, RAJASTHAN, India
Dr Shubhina Gupta
Principal investigator
8308587092
shubhina1492@gmail.com