NCT04912882尚未招募不适用
Prognosis Predicting of CRC Patients Based on Morphology and Molecular Biomaker of Circulating Tumor Cells
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,000
- 主要终点
- Specificity
研究概览
简要总结
Detecting circulating tumor cells from I-IV stage colorectal cancer patients pre-and post-operatively. Analyzing the morphology and biomarkers of CTCs and builting prognosis predicting model based on the morphology and biomarkers of CTCs. Verifying the prognosis model by the survival data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-80 years;
- •Histologically proven colorectal carcinoma (TNM stage I-IV)
- •R0 resection is possible according to preoperative evaluation
- •Written informed consent for participation in the trial.
排除标准
- •Primary tumor or metastases not able to be removed radically
- •Receiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy)
- •Have other malignant tumors meanwhile
- •Other previous malignancy within 5 years
结局指标
主要结局
Specificity
时间窗: 1 year
The specificity of predictive model based on the number and type of circulating tumor cell
Sensitivity
时间窗: 1 year
The sensitivity of the predictive based on the number and type of circulating tumor cell
次要结局
- AUC(1 year)
研究者
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