Amoxicillin-clavulanic acid Levels in Sputum After Nebulizatio
- Conditions
- AECOPD (Acute exacerbation of COPD)inhalationnebulizationantibioticsamoxicillin
- Registration Number
- NL-OMON28084
- Lead Sponsor
- Medisch Spectrum Twente (Medical Center)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 21
Inclusion Criteria
1) A clinical diagnosis of COPD, as defined by GOLD criteria
2) Hospitalized for an acute exacerbation of COPD
Exclusion Criteria
1) Current pneumonia, defined as an acute respiratory tract illness associated with radiographic shadowing on a X-ray or CT-scan of the chest which was neither pre-existing nor of any other cause.
2) Allergy for penicillin, amoxicillin or clavulanic acid.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dose exposure data as determined by sputum concentrations of amoxicillin. Amoxicillin levels in sputum give information on the appropriateness of the dose given from a calculated time > MIC.
- Secondary Outcome Measures
Name Time Method The safety and tolerability of inhalation of nebulized amoxicillin clavulanic acid by adverse effects monitoring.