A clinical trial to assess efficacy of Angiotensin Receptor Nephrilysin Inhibitor (Sacubitril/Valsartan) in right ventricular systolic dysfunction with normal LV functionâ??
Phase 2
- Conditions
- Health Condition 1: I272- Other secondary pulmonary hypertension
- Registration Number
- CTRI/2023/01/049280
- Lead Sponsor
- MDM hospitalDr SN Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of Right Ventricular systolic dysfunction with Normal Left ventricular systolic function as diagnosed by transthoracic echocardiography parameters such as TAPSE( <16mm), PAsP( >25mm Hg), tricuspid annular velocity( <10 cm/sec), Fractional area change( <35%) and blood markers such as NT-proBNp( >400pg/ml).
Exclusion Criteria
1.Patients with LVEF <50%
2.Pregnancy
3. Severe hepatic impairment (Child. Pugh C)
4.Severe renal imapairment (eGFR <30 ml/min/1.73m2)
•Hypersensitivity to any component of the product
•A prior history of angioedema due to an ACEI or ARB
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method