Comparison Between Effect of High Dose and Low Dose of Atorvastatin in Reduction Level of CRP in Patients With Unstable Angina and NSTEMI (Non ST Elevation MI)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- CRP reduction
研究概览
简要总结
The aim of this study is to compare the effect of high dose and low dose of Atorvastatin in reduction level of C-reactive protein (CRP) in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas.
详细描述
This study compare the effect of 80mg atorvastatin followed by two 20mg daily atorvastatin with three 80mg daily atorvastatin in reduction of CRP in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas in 2009.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with unstable angina with chest discomfort at rest with normal EKG or St depression (at least 0.1mv) in two consecutive leads or new and deep T inversion (at least 0.2mv)
排除标准
- •Myocardial Infarction with ST elevation
- •Diabetes Mellitus
- •Previous statin use
- •Current infectious disease
研究组 & 干预措施
High dose atorvastatin
Three 80mg daily doses of atorvastatin
干预措施: Low dose Atorvastatin (Drug)
Low dose Atorvastatin
80mg atorvastatin followed by two 20mg daily atorvastatin
干预措施: High dose atorvastatin (Drug)
结局指标
主要结局
CRP reduction
时间窗: 72 hours
CRP reduction will be compared between two study groups
次要结局
- Drug side effects(72 hours)