Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome

Recruiting

• Conditions: Hepatic Failure; Hypothyroidism; Hepatic Encephalopathy; Hepatic Impairment
• Interventions: Diagnostic Test: hypothroidism; Diagnostic Test: euothyroid

• Registration Number: NCT06179368
• Lead Sponsor: Assiut University

Brief Summary

Liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to triiodothyronine (T3) by Type 1 deiodinase.

Detailed Description

In clinical terms, cirrhosis is described as are either "compensated" or "decompensated." Decompensation means cirrhosis complicated by one or more of the following features: jaundice, ascites, hepatic encephalopathy (HE), or bleeding varices. Ascites is the usual first sign. Hepatorenal syndrome, hyponatremia, and spontaneous bacterial peritonitis are also features of decompensation, but in these patients, ascites invariably occurs first. Compensated cirrhotic patients have none of these features.

The liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to T3 by Type 1 deiodinase.

T4 and T3 regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic function. The liver metabolizes the THS and regulates their systemic endocrine effects. Thyroid diseases may perturb liver function; liver disease modulates thyroid hormone metabolism; and a variety of systemic diseases affect both the organs.

Study Timeline

• Study First Submitted: 2023-12-12
• Study First Submitted QC: 2023-12-12
• Study First Posted: 2023-12-21
• Status Verified: 2024-01
• Study Start: 2024-01-01
• Last Update Submitted: 2024-01-12
• Last Update Posted: 2024-01-16
• Primary Completion: 2024-04-01
• Study Completion: 2024-05-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• hepatic fauiure patients

Exclusion Criteria

• hypethyroid patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hypothroid group	hypothroidism	throid fuction will be evaluated on admission of hepatic failure patients, and the hypothroid patients will be enroled in this group.
Euthroid group	euothyroid	throid fuction will be evaluated on admission of hepatic failure patients, and the euothroid patients will be enroled in this group.

Primary Outcome Measures

Name	Time	Method
short termoutcome	(0 to 30 days)	mortality during hospitalstay

Secondary Outcome Measures

Name	Time	Method
complications	(0 to 30 days)	suchas renal affection, bleeding tendency ...etc

Trial Locations

Locations (1)

Emad Zarief Kamel Said; 🇪🇬 Assiut, Egypt