Thyroid hormone metabolism and innate immunity: the role of deiodinase type 3 in polymorphonuclear leukocytes

Completed

• Conditions: Leukocyte function; 10047954; 10043739; 10002252

• Registration Number: NL-OMON44488
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 38

Inclusion Criteria

Healthy volunteers:
1. Aged >=18
2. Willing and able to provide signed informed consent prior to study-related procedures.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:;1. History of haematological diseases
2. Fever or other symptoms of infection during the past 7 days.
3. Use of medication that could affect haematological parameters or neutrophil function as specified by the Farmacotherapeutisch Kompas (http://www.fk.cvz.nl)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are changes in the amount of D3 protein, D3 activity,<br /><br>bacterial killing capacity and subcellular localisation of D3 in activated<br /><br>versus non-activated leukocytes.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.v.t. </p><br>