Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- The characteristics of the intestinal microbiota in patients with high-risk colorectal polyp recurrence
研究概览
简要总结
The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of patients after polypectomy with recurrence of colorectal polyps. Additionally, this research holds significant importance for understanding the etiology of adenoma recurrence and develop a microbiota and metabolite-based predicting tool.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma
排除标准
- •patient with severe physical diseases that prevented them from adhering to the examination requirements,
- •patient with coagulopathy or other contraindications for biopsy or polypectomy,
- •patient with previous surgical procedures on the gastrointestinal tract,
- •presence of colorectal cancer or other malignant tumor at baseline
- •presence of inflammatory bowel disease or hereditary polyposis syndromes (such as family adenomatous polyposis or Lynch syndrome)
- •within 1 month before enrollment, oral antibiotics and probiotics were taken;
- •inability to provide informed consent or refusal to participate in the study.
结局指标
主要结局
The characteristics of the intestinal microbiota in patients with high-risk colorectal polyp recurrence
时间窗: 24 months
Analyze the characteristics of the microbiota within the intestinal mucosal tissue of patients with high-risk colorectal polyp recurrence or without recurrence.
次要结局
- Development and validation of Microbiota and metabolite-based model predicting recurrence of high-risk colorectal polyps after polypectomy(36 months)
研究者
Jing-Nan Li
Chief physician, Professor
Peking Union Medical College Hospital