A Study Focused on the Host and Microbiome of Colorectal Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Gut microbiota structure and function difference between colorectal cancer, precancer and healthy controls
研究概览
简要总结
Recruit of healthy, precancer and colorectal cancer patients and record necessary information of demographic and also other messages. All the volunteers were asked to provide samples including stool, blood, urine and tissues. This protocol is performed with the permission of the ethics committee and all the participants were provided with informed consent.
详细描述
Healthy subjects, precancer patients identified by colonoscopy or colonoscopy history and colorectal cancer patients identified by two independent pathologists will be enrolled. The demographic message including age, weight, height, drug history, family history of all participants will be recorded. Blood, stool and urine samples will be collected of all subjects. Tumor and adjacent tissue samples of colorectal cancer and precancer patients were collected, as well as normal tissue of healthy subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Any one who can not provide accurate information.
- •Any one who denies the study.
- •Younger than 18.
结局指标
主要结局
Gut microbiota structure and function difference between colorectal cancer, precancer and healthy controls
时间窗: average of 5 years
The results were based on the 16S rRNA metagenomic sequencing.
次要结局
- Metabolic difference of blood samples between colorectal cancer, precancer and healthy controls(average of 5 years)
研究者
Huanlong Qin
Professor
Shanghai 10th People's Hospital