A Study Focused on the Host and Microbiome of Colorectal Cancer Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Colorectal Neoplasms
- Sponsor
- Shanghai 10th People's Hospital
- Enrollment
- 2000
- Locations
- 1
- Primary Endpoint
- Gut microbiota structure and function difference between colorectal cancer, precancer and healthy controls
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
Recruit of healthy, precancer and colorectal cancer patients and record necessary information of demographic and also other messages. All the volunteers were asked to provide samples including stool, blood, urine and tissues. This protocol is performed with the permission of the ethics committee and all the participants were provided with informed consent.
Detailed Description
Healthy subjects, precancer patients identified by colonoscopy or colonoscopy history and colorectal cancer patients identified by two independent pathologists will be enrolled. The demographic message including age, weight, height, drug history, family history of all participants will be recorded. Blood, stool and urine samples will be collected of all subjects. Tumor and adjacent tissue samples of colorectal cancer and precancer patients were collected, as well as normal tissue of healthy subjects.
Investigators
Huanlong Qin
Professor
Shanghai 10th People's Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Any one who can not provide accurate information.
- •Any one who denies the study.
- •Younger than 18.
Outcomes
Primary Outcomes
Gut microbiota structure and function difference between colorectal cancer, precancer and healthy controls
Time Frame: average of 5 years
The results were based on the 16S rRNA metagenomic sequencing.
Secondary Outcomes
- Metabolic difference of blood samples between colorectal cancer, precancer and healthy controls(average of 5 years)