A Cohort of Molecular Characteristics and Prognosis of Colorectal Cancer
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Fudan University
- Enrollment
- 15,000
- Locations
- 1
- Primary Endpoint
- Disease-free survival time
Study Overview
Brief Summary
This study aims to establish a colorectal cancer cohort, collect clinicopathological information, collect biological samples for multi-omics testing, and perform relevant analysis, to predict the prognosis of colorectal cancer, guide the diagnosis and treatment of colorectal cancer and the formulation of health policies.
Detailed Description
In this study, the investigators will establish a database to collect clinical pathological information, based on the medical data system of participating medical centers. The investigators will also collect corresponding tumor specimens and perform multiple omics tests such as genome, transcriptome, and proteome. The investigators will aggregate these data into a special database, and use appropriate methods to conduct big data analysis, to predict prognosis, guide diagnosis and treatment, and assist in formulating health policies.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Pathologically diagnosed as colorectal cancer
- •Receiving any surgery of primary tumor, including palliative resection, simple enterostomy and exploratory surgery
Exclusion Criteria
- •The patient refused to join the study
- •The patient refused to collect the biological sample
- •The patient refused to follow up
Outcomes
Primary Outcomes
Disease-free survival time
Time Frame: 2 yeas after surgery
For patients received radical resection of colorectal cancer, disease-free survival time is defined as time from the surgery to any recurrence of disease or death, recorded in months.
Secondary Outcomes
- Overall survival time(2 yeas after surgery)
- Pathological TNM stage(1 month after surgery)