Comparison of the efficacy of two dialysis filters in removing larger molecules that accumulate in acute renal failure

Completed

Conditions: Acute kidney injury, renal replacement therapy
Injury, Occupational Diseases, Poisoning
Injury of kidney

Registration Number: ISRCTN88486733

Lead Sponsor: Medical School Hannover (Germany)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 11

Inclusion Criteria

1. Males and females
2. Aged > 18 years
3. Patients in the intensive care unit suffering from acute kidney injury [stage Acute Kidney Injury Network (AKIN) III], i.e. need for renal replacement therapy
4. Treatment using the 90 L GENIUS batch dialysis system
5. Signed consent

Exclusion Criteria

1. Pregnant and nursing patients
2. Patients participating in a different study (other than observational)
3. All conditions deemed to justify exclusion by the recruiting physician

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Dialyser clarance of middle molecules<br>2. Total amount of middle molecules in the combined spent dialysate and ultrafiltrate dialyzer clearance measured 30 min after start of treatment for the quantified substances according to equation 1 using the patients? hematocrit level (Hct) at the time of clearance sampling.<br>Eq. 1: Kplasma = QB x (1 ? Hct/100) x ((Cart ? Cven)/Cart)<br>3. Reduction ratio (RR) determined for beta2-microglobulin, creatinine, cystatin c and urea. Therefore, blood samples will be collected right before the start (Cpre) as well as at the end (Cpost) of the treatment. Calculations of RR executed according to equation 2.<br>Eq. 2: RR = (Cpost ? Cpre)/Cpre x 100<br>Samples of the total spent dialysate will be drawn at the end of the treatment.

Secondary Outcome Measures

Name	Time	Method
Albumin loss<br>Total loss of albumin by adding the albumin values in the total spent dialysate and ultrafiltrate. For concentrations below the detection limit of 1.1 mg/dl, an albumin concentration of 1.1 mg/dl was assumed.<br>Eq. 3: Alb = Calb(dialysate) x Vdialysate + Calb(ultrafiltrate) x Vultrafiltrate