Apalutamide in Treating Patients With Prostate Cancer Before Radical Prostatectomy

Phase 2

Active, not recruiting

Conditions: Prostate Adenocarcinoma
Stage IIB Prostate Cancer AJCC v8

Interventions: Drug: Apalutamide
Other: Quality-of-Life Assessment
Procedure: Radical Prostatectomy

Registration Number: NCT03412396

Lead Sponsor: M.D. Anderson Cancer Center

Brief Summary: This phase II trial studies how well apalutamide works in treating patients with prostate cancer before radical prostatectomy. Androgen can cause the growth of prostate cancer cells. Hormone therapy using apalutamide may fight prostate cancer by lowering the amount of androgen the body makes and may make it less likely for patients to receive radiation therapy after surgery.

Detailed Description: PRIMARY OBJECTIVE:

I. To determine whether 6 months (24 weeks) of neoadjuvant apalutamide prior to prostatectomy for intermediate risk prostate cancer results in a reduction of aggregate pathologic risk features that drive post-operative radiotherapy recommendations from 35% to 15%.

SECONDARY OBJECTIVES:

I. To determine the safety and tolerability of 6 months (24 weeks) neoadjuvant apalutamide followed by radical prostatectomy for intermediate risk prostate cancer.

II. To estimate the frequency of clinical complete responses and "near" complete responses (currently defined as \< 6 mm total tumor volume).

III. To characterize the molecular features of the treated prostate cancers and link them to morphologic characterization.

IV. To measure the 3-5 year biochemical recurrence rate of treated patients as a baseline to inform a larger phase III trial.

OUTLINE:

Patients receive apalutamide orally (PO) daily for 24 weeks in the absence of disease progression or unacceptable toxicity. Within 2 weeks of completing apalutamide, patients undergo radical prostatectomy.

After completion of study treatment, patients are followed up at 12 months.

Recruitment & Eligibility

Status: ACTIVE_NOT_RECRUITING

Sex: Male

Target Recruitment: 45

Inclusion Criteria

Willing and able to provide written informed consent
Histologically confirmed adenocarcinoma of the prostate
A minimum of 10 core biopsies have been performed at baseline and available. A prostate biopsy within 6 months from screening is allowed for entry requirements. Biopsies performed within 6-12 months from screening are acceptable if the treating physician would allow treatment without further biopsy. Patients must meet intermediate risk criteria from Gleason score, T stage, and prostate-specific antigen (PSA) value by National Comprehensive Cancer Network (NCCN) criteria: cT2b-T2c or Gleason 7 (3+4 or 4+3) or PSA 10-20 ng/mL. In addition, the Gleason 3+4 or 4+3 must be present
Pathology review at MD Anderson Cancer Center. The volume of disease must be high enough for the surgeon to agree to include an extended template pelvic lymph node dissection
Serum testosterone > 200 ng/mL
Patient and urologist must agree that patient is suitable for prostatectomy
No evidence of metastases on imaging. This risk group does not require metastatic studies, but if performed they must be negative (as determined by urologist or radiologist). Suspicious lymph nodes permissible if < 10 mm
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
Hemoglobin >= 10.0 g/dL
Platelet count >= 100,000 x 10^9/microliter
Glomerular filtration rate (GFR) >= 45 mL/min
Serum potassium >= 3.5 mmol/L
Serum albumin >= 3.0 g/dL
Able to swallow the study drug whole as a tablet
Serum bilirubin < 1.5 x upper limit of normal (ULN); Note: In subjects with Gilbert's syndrome, if total bilirubin is > 1.5 x ULN, measure direct and indirect bilirubin and if direct bilirubin is =< 1.5 x ULN, subject may be eligible
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x ULN
Normal coagulation profile and no history of substantial non-iatrogenic bleeding diathesis
Agrees to use a condom (even men with vasectomies) and another effective method of birth control if he is having sex with a woman of childbearing potential or agrees to use a condom if he is having sex with a woman who is pregnant while on study drug and for 3 months following the last dose of study drug. Must also agree not to donate sperm during the study and for 3 months after receiving the last dose of study drug

Exclusion Criteria

Histological variants in the primary tumor, other than adenocarcinoma; for example: neuroendocrine tumor, small cell or sarcomatoid
Serious or uncontrolled co-existent non-malignant disease, including active and uncontrolled infection
PSA is > than 20 ng/mL (NOTE: unless other valid PSAs were =< 20 and the treating physician considers a value > 20 related to the biopsy or other non-malignant cause. The treating physician must consider the patient intermediate risk in aggregate)
Uncontrolled hypertension. Patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive therapy. Note that this is NOT a criterion related to particular blood pressure (BP) results at the time of assessment for eligibility, nor does it apply to acute BP excursions that are related to iatrogenic causes, acute pain or other transient, reversible causes
Active or symptomatic viral hepatitis or chronic liver disease
Clinically significant heart disease as evidenced by myocardial infarction, arterial thrombotic events in the past 6 months, severe or unstable angina, class III-IV New York Heart Association heart failure
Other malignancy, except non-melanoma skin cancer, that is active or has a >= 30% probability of recurrence within 12 months
History of gastrointestinal disorders (medical disorders or extensive surgery) which may interfere with the absorption of the study drug
Known history of pituitary and/or adrenal disease (or dysfunction)
Prior hormone therapy for prostate cancer including orchiectomy, antiandrogens, ketoconazole, or estrogens (5-alpha reductase inhibitors allowed), or luteinizing hormone-releasing hormone (LHRH) agonists/antagonists
Severely compromised immunological state, including being positive for the human immunodeficiency virus (HIV)
Patients who are not appropriate surgical candidates for radical prostatectomy based on the evaluation of co-existent medical diseases and competing potential causes of death (such as but not limited to, unstable angina, myocardial infarction within the previous 6 months, or use of ongoing maintenance therapy for life-threatening ventricular arrhythmia, uncontrolled hypertension)
History of seizure, seizure disorder, or any condition that may predispose to seizure including, but not limited to underlying brain injury, stroke, primary brain tumors, brain metastases, or alcoholism. Also, history of loss of consciousness or transient ischemic attack within 12 months of enrollment (day 1 visit). Drugs may not be used which are known to decrease the seizure threshold

Study & Design

Study Type: INTERVENTIONAL

Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Treatment (apalutamide, radical prostatectomy)	Quality-of-Life Assessment	Patients receive apalutamide PO daily for 24 weeks in the absence of disease progression or unacceptable toxicity. Within 2 weeks of completing apalutamide, patients undergo radical prostatectomy.
Treatment (apalutamide, radical prostatectomy)	Radical Prostatectomy	Patients receive apalutamide PO daily for 24 weeks in the absence of disease progression or unacceptable toxicity. Within 2 weeks of completing apalutamide, patients undergo radical prostatectomy.
Treatment (apalutamide, radical prostatectomy)	Apalutamide	Patients receive apalutamide PO daily for 24 weeks in the absence of disease progression or unacceptable toxicity. Within 2 weeks of completing apalutamide, patients undergo radical prostatectomy.

Primary Outcome Measures

Name	Time	Method
Number of Adverse Surgical Pathology Features at Risk of Pelvic Radiation Therapy	Assessed at time of surgical specimen microscopic evalution Assessed at time of surgical specimen microscopic evaluation	To determine whether 6 months (24 weeks) of neoadjuvant apalutamide prior to prostatectomy for intermediate risk prostate cancer results in a reduction of surgical pathology features at risk of pelvic RT, defined as pT3a, pT3b stage, N1 and/or positive surgical margin. All patients who receive at least 9 weeks of neoadjuvant therapy of apalutamide and undergo radical prostatectomy will be evaluable for the primary endpoint.

Secondary Outcome Measures

Name	Time	Method
Safety and Tolerability of 6 Months Neoadjuvant Apalutamide Followed by Radical Prostatectomy	From initiation of apalutamide through 30 days post-surgery. For those participants who did not have surgery, we assessed the reported AEs until 30 days after the last dose of apalutamide.	Incidence of treatment emergent adverse events (TEAEs). All patients who receive any dose of apalutamide will be evaluable for safety.
Clinical Complete Responses (pT0) and "Near" Complete Responses (<6mm Total Tumor Volume)	Assessed at time of surgical specimen microscopic evaluation	The numbers of patients with \<6 mm total tumor volume in their surgical specimens, assessed by study Pathologist.
Biochemical Recurrence Rate	From surgery through 3-year post-op follow up	Number of patients who had a PSA value of equal of more than 0.2 ng/dL after surgery and through 3 years of follow up.