Feasibility of Ultrasound guided aspiration ofSynovia) fluid from Inflamed Small hand joints.
Recruiting
- Conditions
- Hand osteoarthritis (OA), rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients.
- Registration Number
- NL-OMON26127
- Lead Sponsor
- eiden University Medical Center (LUMC)
- Brief Summary
not yet applicable
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Diagnoses of hand OA, rheumatoid arthritis, or psoriatic arthritis according to recognised classification criteria sets;
2. Presence of an inflamed interphalangeal or MCP joint for which the treating rheumatologist has proposed treatment with an intra-articular injection with corticosteroids;
Exclusion Criteria
1. Patients that had an intra-articular injection with corticosteroids, an operation or an important trauma in the same joint less than 12 weeks before the intended injection;
2. The presence of a chronic inflammatory disease (other than OA, rheumatoid
arthritis or psoriatic arthritis), such as poly-articular gout;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The percentage of study joints in which a successful aspiration is performed.
- Secondary Outcome Measures
Name Time Method The volume of the obtained synovia) fluid collections (~I);<br /><br>• To analyse the presence of cytokines (such as IL-1, IL-6, IL-8, TNF-a), of immune cells (neutrophils, macrophages, lymphocytes) and adipokines and lipid mediators in the synovia) fluid;<br /><br>• The relation between the US effusion score and volume of synovia) fluid that is aspirated from the study joint.