Letrozole Versus Laparoscopic Ovarian Diathermy for Ovulation Induction in Clomiphene-resistant Women With Polycystic Ovary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 260
- 试验地点
- 1
- 主要终点
- occurrence of ovulation and midcycle endometrial thickness (mm).
研究概览
简要总结
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of laparoscopic ovarian diathermy (LOD) in infertile women with Polycystic ovary syndrome(PCOS)not responding to treatment with Clomiphene alone.
详细描述
In the letrozole group, withdrawal bleeding was achieved using 10 mg of dydrogesterone tablets for 10 days before stimulation, then 2.5 mg of letrozole oral tablets (Femara; Novartis Pharma Services, Switzerland) daily from day 3 of the menses for 5 days up to six cycles. All patients in the control group underwent laparoscopic ovarian diathermy, then followed up for 6 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 36 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •CC resistant PCOS
排除标准
- •Congenital adrenal hyperplasia
- •Cushing syndrome
- •Androgen secreting tumors
研究组 & 干预措施
Letrozole
2.5 mg letrozole oral tablets daily from day 3 of the menses for 5 days up to 6 cycles
干预措施: Letrozole (Drug)
Laparoscopic ovarian diathermy (LOD)
Three-puncture technique. Each ovary was cauterized at four points, each for 4 seconds at 40 W for a depth of 4 mm with a mixed current, using an monopolar electrosurgical needle.
干预措施: Laparoscopic ovarian diathermy (LOD) (Procedure)
结局指标
主要结局
occurrence of ovulation and midcycle endometrial thickness (mm).
次要结局
- occurrence of pregnancy, miscarriage, multiple pregnancy and live birth rates.