Metabolic Exercise Testing

Recruiting

• Conditions: Metabolic Myopathies; Exercise Test; Myalgia

• Registration Number: NCT02362685
• Lead Sponsor: University Hospital, Brest

Brief Summary

Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-09
• Study First Submitted: 2015-02-04
• Study First Submitted QC: 2015-02-12
• Study First Posted: 2015-02-13
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-21
• Last Update Posted: 2020-01-22
• Primary Completion: 2027-12
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Referred to the Physiology Department of Brest Hospital for a metabolic exercise test
• Ability to provide informed consent

Exclusion Criteria

• Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)
• Pregnancy or unknown pregnancy status.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Whole-body dynamic exercise	Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed	The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Grip-test	Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed	The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Blood tests	Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed	The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.

Trial Locations

Locations (1)

Centre Hospitalier Régional Universitaire; 🇫🇷 Brest, France