Targeting the Skeletal Muscle to Treat Metabolic Dysfunction-associated Steatotic Liver Disease

Not Applicable

Not yet recruiting

• Conditions: Metabolic Dysfunction-associated Steatotic Liver Disease
• Interventions: Other: Low intensity exercise training; Other: Moderate intensity exercise training; Other: High-intensity interval training

• Registration Number: NCT06506513
• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Brief Summary

Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.

Detailed Description

In this monocenter interventional study, we will assess the impact of physical activity on muscle fat content and liver disease severity in MASLD as well as the mechanisms mediating the potential beneficial effects of exercise.

Study Timeline

• Study First Submitted: 2024-06-27
• Status Verified: 2024-07
• Study First Submitted QC: 2024-07-11
• Last Update Submitted: 2024-07-11
• Study First Posted: 2024-07-17
• Last Update Posted: 2024-07-17
• Study Start: 2024-10
• Primary Completion: 2025-10
• Study Completion: 2026-09

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• confirmed MASLD at abdominal imaging
• confirmed excessive muscle lipid content at imaging
• stable weight

Exclusion Criteria

• severe comorbidities including active malignancies, neuromuscular degenerative diseases
• contraindications to physical activity
• excessive alcohol consumption

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	Low intensity exercise training	in this control group, patients will perform non-cardiovascular non-intensity training (stretching, meditation).
moderate-intensity low interval training group	Moderate intensity exercise training	In this group, patients will perform moderate-intensity low interval training.
high-intensity interval training	High-intensity interval training	In this group, patients willp erform high-intensity interval training.

Primary Outcome Measures

Name	Time	Method
the impact of physical activity on muscle and liver phenotypes	every four weeks from baseline till study completion	the investigators will assess at baseline and every four weeks till study completion the impact of intervention on liver phenotype assessed by transient elastography and muscle phenotype assessed by MRI

Trial Locations

Locations (2)

Centre d'investigation clinique en nutrition; 🇧🇪 Louvain-La-Neuve, Belgium

Cliniques universitaires Saint-Luc; 🇧🇪 Brussels, Belgium