Targeting Myosteatosis Though Physical Exercise to Treat Metabolic Dysfunction-associated Steatotic Liver Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 3
- Primary Endpoint
- the impact of physical activity on muscle and liver phenotypes
Study Overview
Brief Summary
Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.
Detailed Description
In this monocenter interventional study, we will assess the impact of physical activity on muscle fat content and liver disease severity in MASLD as well as the mechanisms mediating the potential beneficial effects of exercise.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •confirmed MASLD at abdominal imaging
- •confirmed excessive muscle lipid content at imaging
- •stable weight
Exclusion Criteria
- •severe comorbidities including active malignancies, neuromuscular degenerative diseases
- •contraindications to physical activity
- •excessive alcohol consumption
Arms & Interventions
moderate-intensity low interval training group
In this group, patients will perform moderate-intensity low interval training.
Intervention: Moderate intensity exercise training (Other)
high-intensity interval training
In this group, patients willp erform high-intensity interval training.
Intervention: High-intensity interval training (Other)
control group
in this control group, patients will perform non-cardiovascular non-intensity training (stretching, meditation).
Intervention: Low intensity exercise training (Other)
Outcomes
Primary Outcomes
the impact of physical activity on muscle and liver phenotypes
Time Frame: every four weeks from baseline till study completion
the investigators will assess at baseline and every four weeks till study completion the impact of intervention on liver phenotype assessed by transient elastography and muscle phenotype assessed by MRI
Secondary Outcomes
No secondary outcomes reported