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Clinical Trials/NCT01961427
NCT01961427CompletedNot Applicable

Dose and Response of Dietary and Inorganic Nitrate in Healthy and Active Men

Swiss Paraplegic Research, Nottwil2 sites in 1 country21 target enrollmentStarted: June 1, 2013Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
21
Locations
2
Primary Endpoint
oxygen consumption
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

It was shown by some researchers that dietary nitrate such as beet root juice can lower oxygen consumption in men and act as a performance enhancing supplement.

It was not shown, what the optimal dosage is and if there is any difference in oxygen consumption comparing beet root juice and inorganic nitrate.

Therefore, the aim of the study is to conduct a study ingesting different sodium nitrate and beet root juice dosages. We would measure nitrate and nitrite concentrations in the blood at different time points and the subjects have to perform an exercise test measuring oxygen consumption 3 hours after the ingestion of nitrate.

Detailed Description

  1. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Every hour a blood withdrawal is taken to measure nitrate and nitrite concentration in the blood.
  2. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Three hours after the intake of the supplement the subjects have to perform an exercise test on a bicycle. They have to cycle 5 min at 50% of maximal oxygen consumption and 8min at 80% of maximal oxygen consumption separated by a 5min break. Oxygen consumption would be measured during the whole exercise test. Blood withdrawal is taken before the ingestion, after 3 hours and after the test.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Factorial
Primary Purpose
Treatment
Masking
Triple (Participant, Care Provider, Outcomes Assessor)

Eligibility Criteria

Ages
18 Years to 45 Years (Adult)
Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •age 18 to 45
  • •healthy active men
  • •non-smoking

Exclusion Criteria

  • •medication intake during study phase

Outcomes

Primary Outcomes

oxygen consumption

Time Frame: 30min

Oxygen consumption during exercise protocol

Secondary Outcomes

  • Nitrate and nitrite concentration(6 hours)
  • oxygen saturation(6 hours)
  • Rating of perceived exertion (RPE)(during the 7 weeks of study phase)
  • Blood pressure(6 hours)
  • Heart rate(during the 7 weeks of study phase)

Investigators

Sponsor
Swiss Paraplegic Research, Nottwil
Sponsor Class
Network
Responsible Party
Sponsor

Study Sites (2)

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