Effect of Nitrate-rich Beetroot Juice on Exercise Performance in Heart Failure Patients
- Conditions
- Systolic Heart Failure
- Interventions
- Dietary Supplement: nitrate-rich beetroot juiceDietary Supplement: nitrate-deplete beetroot juice
- Registration Number
- NCT02223403
- Lead Sponsor
- Brooke Army Medical Center
- Brief Summary
Nitrate-rich beetroot juice supplementation has demonstrated reduced oxygen consumption and submaximal exercise performance in healthy adults. Investigation for similar effects in patients with heart failure has not previously been conducted.
This was a randomized, double-blind, placebo controlled trial. Following ingestion of the active agent or placebo, subjects with systolic heart failure underwent submaximal steady state exercise with gas exchange analysis followed thirty minutes later by a six minute walk test. Second testing sessions were performed ten days.
There were no significant differences in the treatment and placebo arms in average oxygen consumption or six minute walk distance.
In conclusion, in patients with heart failure who have ingested a single dose of nitrate-rich beetroot juice concentrate, there is no significant difference with regard to oxygen consumption during submaximal steady state exercise or six minute walk testing distance.
Further study is warranted to determine the true efficacy of nitrate consumption in this population with adjustments in acute or chronic dosing, exercise duration, or intensity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
- Local institutional beneficiaries between the ages of 18 and 80
- Documentation of left ventricular systolic dysfunction with ejection fraction < 40% by any modality within the past six months
- Documentation of New York Heart Association class II or III status.
- > 80 years of age
- Unable to adequately or safely perform treadmill exercise
- Pulmonary disease deemed significant enough to be a limitation to exercise
- Greater than moderate stenotic or regurgitant valvular heart disease
- Presence of atrial fibrillation or other uncontrolled arrhythmias
- Uncompensated heart failure
- Continuously paced rhythms
- Pregnant females
- Chronic nitroglycerine use (oral isosorbide di or mono-nitrate, or topical nitroglycerine)
- Phosphodiesterase inhibitor (sildenafil or tadalafil) use within a week
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description submaximal steady state exercise nitrate-rich beetroot juice 90 minutes after respective beetroot juice ingestion, subjects walked on treadmill at a pre-determined steady state workload for a total of 15 minutes with oxygen consumption recorded for the last 10 minutes submaximal steady state exercise nitrate-deplete beetroot juice 90 minutes after respective beetroot juice ingestion, subjects walked on treadmill at a pre-determined steady state workload for a total of 15 minutes with oxygen consumption recorded for the last 10 minutes six minute walk test nitrate-deplete beetroot juice subjects performed six-minute walk at self-determined pace 30 minutes after treadmill exercise was performed six minute walk test nitrate-rich beetroot juice subjects performed six-minute walk at self-determined pace 30 minutes after treadmill exercise was performed
- Primary Outcome Measures
Name Time Method six minute walk distance six minutes subjects walked at their chosen pace for six minutes on a pre-determined course. Total distance was recorded.
steady state exercise oxygen consumption 10 minutes Subjects performed steady state treadmill walking at a pre-determine submaximal workload. Oxygen consumption was measured for the last 10 minutes.
- Secondary Outcome Measures
Name Time Method