Dose and Response of Dietary Nitrate in Healthy and Active Men

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT01961427
• Lead Sponsor: Swiss Paraplegic Research, Nottwil

Brief Summary

It was shown by some researchers that dietary nitrate such as beet root juice can lower oxygen consumption in men and act as a performance enhancing supplement.

It was not shown, what the optimal dosage is and if there is any difference in oxygen consumption comparing beet root juice and inorganic nitrate.

Therefore, the aim of the study is to conduct a study ingesting different sodium nitrate and beet root juice dosages. We would measure nitrate and nitrite concentrations in the blood at different time points and the subjects have to perform an exercise test measuring oxygen consumption 3 hours after the ingestion of nitrate.

Detailed Description

1. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Every hour a blood withdrawal is taken to measure nitrate and nitrite concentration in the blood.

2. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Three hours after the intake of the supplement the subjects have to perform an exercise test on a bicycle. They have to cycle 5 min at 50% of maximal oxygen consumption and 8min at 80% of maximal oxygen consumption separated by a 5min break. Oxygen consumption would be measured during the whole exercise test. Blood withdrawal is taken before the ingestion, after 3 hours and after the test.

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2013-10-09
• Study First Submitted QC: 2013-10-09
• Study First Posted: 2013-10-11
• Primary Completion: 2016-06
• Status Verified: 2016-11
• Study Completion: 2016-11
• Last Update Submitted: 2016-11-18
• Last Update Posted: 2016-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 21

Inclusion Criteria

• age 18 to 45
• healthy active men
• non-smoking

Exclusion Criteria

• medication intake during study phase

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
oxygen consumption	30min	Oxygen consumption during exercise protocol

Secondary Outcome Measures

Name	Time	Method
Nitrate and nitrite concentration	6 hours	every hour for the six hours after the ingestion of dietary/inorganic nitrate, nitrate and nitrite concentration in the blood is analyzed.
oxygen saturation	6 hours	every hour oxygen saturation is measured.
Rating of perceived exertion (RPE)	during the 7 weeks of study phase	RPE is measured after the low-intensity exercise performance and after the submaximal exercise performance.
Blood pressure	6 hours	every hour, blood pressure is measured.
Heart rate	during the 7 weeks of study phase	Heart rate is measured before the ingestion, before the exercise test and during the exercise test. resting heart rate is additionally measured every hours after the intake of dietary/inorganic nitrate.

Trial Locations

Locations (1)

Swiss Paraplegic Centre; 🇨🇭 Nottwil, Lucerne, Switzerland