The Influence of Menopausal Status on Myocardial Stiffness and Exercise Capacity Among Female Masters Endurance Athletes.

Recruiting

• Conditions: Myocardial Stiffness
• Interventions: Diagnostic Test: Stress Echocardiogram; Diagnostic Test: Cardiovascular Magnetic Imaging (cMRI); Diagnostic Test: Cardiac Magnetic Resonance Elastography (cMRE)

• Registration Number: NCT06475768
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-06-21
• Study First Submitted QC: 2024-06-21
• Study First Posted: 2024-06-26
• Study Start: 2024-09-14
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-09
• Last Update Posted: 2025-04-11
• Primary Completion: 2026-07
• Study Completion: 2026-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Longstanding history of competitive endurance athletic performance defined as >15 years of continuous athletic training for at least 7 hours per week and ongoing engagement in competitive events.

Exclusion Criteria

• A current or prior diagnosis of cardiovascular disease as defined by the presence of structural heart disease, heart failure, symptomatic coronary artery disease, more than moderate valve disease or prior valve surgery,
• Current or recent pregnancy within 1 year
• Positive pregnancy test (study visit 1)
• Concurrent or use within 1 year of oral contraceptives or hormone replacement therapy,
• Unable to undergo a cMRI (Please refer standard clinical contraindications for MRI)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Male Athletes	Cardiac Magnetic Resonance Elastography (cMRE)	-
Premenopausal Female Athletes	Cardiovascular Magnetic Imaging (cMRI)	-
Postmenopausal Female Athletes	Stress Echocardiogram	-
Premenopausal Female Athletes	Cardiac Magnetic Resonance Elastography (cMRE)	-
Postmenopausal Female Athletes	Cardiovascular Magnetic Imaging (cMRI)	-
Postmenopausal Female Athletes	Cardiac Magnetic Resonance Elastography (cMRE)	-
Male Athletes	Stress Echocardiogram	-
Male Athletes	Cardiovascular Magnetic Imaging (cMRI)	-
Premenopausal Female Athletes	Stress Echocardiogram	-

Primary Outcome Measures

Name	Time	Method
Myocardial stiffness	Day 14	Myocardial stiffness will be measured by magnetic resonance elastography (kPa)

Secondary Outcome Measures

Name	Time	Method
Left ventricular filling pressures with exercise	Baseline	Left ventricular filling pressures with exercise will be measured by stress echocardiography
Exercise capacity	Baseline	Exercise capacity will be measured by stress echocardiography

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States