Trigonella, Foeniculum, Chichorium, Hornleum and Glycine in prevention of cancer-induced cachexia/anorexia
- Conditions
- Cancer-induced cachexia.C80.0C80.9
- Registration Number
- IRCT20180722040556N1
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
All adult patients (18 years and older) with advanced solid tumor malignancies (Stage 3-4) who encountered cancer-induced anorexia or weight loss (equal or greater than 5% of the previous weight before cancer diagnosis or within the last two months).
Cancer patients with serum creatinine < 2 mg / dl.
Cancer patients with serum total bilirubin < 2 mg / dl.
Patients haven't had any sign of dysphagia or gastrointestinal obstruction.
We have expected patients to be alive at least 3 upcoming months.
Patients who have received high doses of megestrol due to cachexia and anorexia simultaneously.
Patients who have undergone major surgery for the last 4 weeks.
Patients with a history of thrombophlebitis diseases.
Patients who have been taking systemic corticosteroid within the last 4 weeks or concurrently.
Patients who have cognitive impairment, psychiatric disorder or brain metastasis leading to cognitive impairment.
Patients who have diabetes, uncontrolled blood pressure or advanced heart failure (NYHA 4)
Patients who have consumed chronic alcohol.
Patients who are pregnant or breast-feeding.
Patients with a known hypersensitivity reaction to one of the plants in considered herbal combination
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of herbal combination consists of Trigonella, Foeniculum, Chichorium, Hornleum, and Glycine in the prevention of cancer-induced cachexia/anorexia. Timepoint: Baseline and 4 weeks later. Method of measurement: Edmonton criteria.
- Secondary Outcome Measures
Name Time Method Quality of life. Timepoint: Baseline and four weeks later. Method of measurement: Iranian Version of the EORTC QLQ.