Low-dose Hydrocortisone in Acutely Burned Patients
Phase 4
Completed
- Conditions
- Burns
- Registration Number
- NCT00149123
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those seen in septic shock. After the initial hypovolemic phase, patients with extensive burns often present a shock with increased cardiac output and reduced systemic vascular resistances. As described in septic shock, we test the hypothesis that low-dose hydrocortisone could decrease the duration of the shock period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- males and females,
- between 18 and 75 year old
- who present a burned surface more than 30% of the body surface
- who need catecholamine infusion
- between J0 and J3 after the injury.
Exclusion Criteria
- pregnancy,
- trauma,
- sepsis,
- cardiac insufficiency,
- AIDS,
- etomidate administration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Number of patients who do not receive any more catecholamine 4 days after the beginning of the shock
- Secondary Outcome Measures
Name Time Method Duration of catecholamine administration Doses of administered catecholamine Adrenal insufficiency incidence
Trial Locations
- Locations (1)
Sylvie TISSOT
🇫🇷Lyon, France
Sylvie TISSOT🇫🇷Lyon, France