Head-To-Head Comparision of Personal Vaporizers Versus Cigalike: Prospective 6-Month Randomized Control Design Study

RATIONALE

The results of ECLAT - the first randomized controlled trial addressing the impact of electronic cigarette use in relation to smoking reduction, smoking abstinence and safety long-term - have revealed important and persistent modifications in the smoking habits of 300 smokers (not intending to quit) with significant reduction in tobacco cigarettes' consumption (1).

Surprisingly, the reduction in cig/day use in ECLAT was not much different among study groups, with the non-nicotine study group performing much like both high and low nicotine study groups. This was because, with the products used in ECLAT, saliva cotinine levels were well below the concentration threshold considered to be representative for regular smokers (2) or experienced electronic cigarette users (3) in both high and low nicotine study groups. Specifically, the model under investigation in ECLAT is not very efficient at delivering nicotine (4).

With this in mind, we have designed a pilot study to compare efficiency and tolerability of a personal vaporizers (PV) new generation electronic cigarette loaded with nicotine e-liquid with cigalike new generation electronic cigarette loaded with nicotine and usual smoking habits, in a group of well characterized regular smokers unwilling to quit.

STUDY OBJECTIVES