Effects of n3 PUFA Supplementation on the Attenuation of Muscle Disuse Atrophy in Young Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Muscle Volume
研究概览
简要总结
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in women undergoing 2 weeks of unilateral limb immobilization. Assessments in skeletal muscle strength and skeletal muscle volume will also me made before, after and in recovery from immobilization.
详细描述
Biological aging is associated with the loss of skeletal muscle mass and strength resulting in compromised metabolic function and mobility. Throughout life, individuals will also experience periods of reduced physical activity/muscle disuse that independently lower muscle mass and strength accelerating the aging process. The losses in muscle mass with aging and disuse are underpinned by feeding-induced declines in rates of muscle protein synthesis. Thus, strategies to enhance muscle protein synthesis could have clinical implications for those who wish to maintain metabolic health and function during times of muscle disuse.
Supplementation with n3 PUFA-enriched fish oil has been shown to potentiate rates of muscle protein synthesis in response to simulated feeding in both younger and older adults. Fish oil supplementation also has been efficacious in enhancing skeletal muscle strength during a period of resistance exercise training. However, no study has examined the impact of fish oil supplementation to enhance muscle protein synthesis and offset declines in muscle mass/strength during a period of immobilization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Aged 18-30 years
排除标准
- •Take any analgesic or anti-inflammatory drugs(s), prescription or non-prescription, chronically will be excluded
- •A history of neuromuscular problems or muscle and/or bone wasting diseases
- •Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
- •Use medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
- •Fish allergy
研究组 & 干预措施
n3 PUFA
Intervention: n3 PUFA (3000mg of Eicosapentaenoic acid per day and 1800mg of Docosahexaenoic acid per day)
干预措施: n3 PUFA-enriched fish oil (Dietary Supplement)
Placebo
Intervention: Organic Sunflower Oil 5000mg per day
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Muscle Volume
时间窗: Baseline (0 days), After (14 days) of unilateral limb immobilization and at 14 days post immobilization
Change in Muscle Volume Measured by Magnetic Resonance Imaging
次要结局
- Skeletal Muscle Strength(Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization)
- Muscle Lipid Composition(Baseline (-28 days), and at Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization)
- Integrated Rates of Muscle Protein Synthesis(Before (0 days), During (0-14 days inclusive), and After (14-28 days inclusive) of unilateral limb immobilization)
研究者
Stuart Phillips
Professor
McMaster University