Ocular surface evaluation in ocular hypertension or inicial glaucoma patients treated with drops.

Not Applicable

• Conditions: H40.0; H40.1; Ocular hypertension or Open angle Glaucoma with no previous treatment.

• Registration Number: RBR-7mmp6k
• Lead Sponsor: niversidade Federal de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-04-24
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Glaucoma or ocular hypertension patients with no previous topical hypotensive treatment.

Exclusion Criteria

Previous ocular surgery, active ocular inflammation or clinically diagnosed dry eye.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IOP Reduction evaluated by ocular tonometry with Goldman Tonometry always at same time (8 am), comparing IOP measurements media pre and post-treatment

Secondary Outcome Measures

Name	Time	Method
Ocular Surface Changes induced by medications used evaluated by break-up time ( TBUT: normal values over 15 seconds), Schirmmer test (normal above 15mm),Green Lissamine vital stainig ( graduated from zero to 9)and changes of score values of OSDI form between inicial and final evaluation.<br>Celular architecture will be evaluated using impression cytology technique and inflammatory parameters will be detected by immunohistochemistry ( HLA-DR and IL-6).