KCT0004214
Completed
未知
Ocular surface changes after combination therapy of hyaluronate 0.15% and hyaluronate 0.3% in dry eye patients.
ConditionsDiseases of the eye and adnexa
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Diseases of the eye and adnexa
- Sponsor
- Keimyung University Dongsan Medical Center
- Enrollment
- 90
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Individuals aged 19 or over who presented with the following criteria after usage of 0\.15% HA in the run\-in period were enrolled: bilateral DED no less than level 2, tear break\-up time (TBUT) less than 10 seconds, corneal fluorescein staining (CFS) score of at least 1 or more by the National Eye Institute (NEI/Industry) grading system, and 33 or more ocular surface disease index (ODSI) severity scale.
Exclusion Criteria
- •At the baseline examination, patients with mild DED (level 1\), TBUT \>10 seconds, CFS score \<1, and ODSI score \<33 (at end of run\-in period) were excluded. Patients with previous ocular pathologies requiring treatment, previous corneal or intraocular surgery within 6 months of the screening visit, a punctal occlusion procedure within 1 month of the screening visit, use of soft contact lenses during the study, measured intraocular pressure over 25 mmHg at the screening visit, and a significant hypersensitivity reaction to HA, as well as patients who were pregnant, breastfeeding, or planning to become pregnant were also excluded.
Outcomes
Primary Outcomes
Not specified
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