The prevalence of brain white matter lesions after pregnancy and the relationship with neurocognitive functioning
Completed
- Conditions
- cognitionPregnancy100098411000796310010273
- Registration Number
- NL-OMON37705
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 62
Inclusion Criteria
One group of women who were never pregnant will be included in this study. Women will be recruited by means of an invitation which will be spread in local newspapers and on the internet. Women can reply to this invitation. From the repliers, 62 women will be matched for age and level of education with a healthy parous woman from a previous study.
Exclusion Criteria
- Any pregnancy of more than 12 weeks gestation or current pregnancy
- Epilepsy or other neurologic disorder
- Pregnancy
- General MRI contraindications or claustrophobia
- Known cerebrovascular disease
- History of alcohol or substance abuse requiring therapy
- Insufficient comprehension of Dutch language
- Fertility treatment or diagnostic procedures
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the prevalence of white matter lesions assessed by<br /><br>MRI using a 3 Tesla MRI.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary study parameters are:<br /><br><br /><br>Scores on the questionnaires: cognitive failures questionnaire (CFQ), hospital<br /><br>anxiety and depression questionnaire (HADS), Utrechtse coping lijst (UCL).<br /><br><br /><br>Scores on neurocognitive tests:<br /><br>- Nederlandse Leestest voor Volwassenen (NLV)<br /><br>- Wechsler Adult Intelligence Scale (WAIS) III letter-number sequencing and<br /><br>digit span, digit-symbol coding, symbol search<br /><br>- Corsi Block-Tapping Task<br /><br>- 15-Word Learning test<br /><br>- Location Learning test<br /><br>- Grooved Pegboard<br /><br>- Groningen Intelligence Test (GIT) II figure exploration<br /><br>- Delis-Kaplan Executive Function System (D-KEFS) Trail Making test, Tower test<br /><br>- STROOP Color Word test<br /><br>- Verbal Fluency test<br /><br>- Figure Fluency test<br /><br>- Amsterdam Short-Term Memory (ASTM) test</p><br>