Submaximal cardiopulmonary exercise testing in patients with knee osteoarthritis scheduled for total knee arthroplasty: a feasibility study.

Completed

• Conditions: gonarthrosis; knee osteoarthritis; 10023213; 10005944

• Registration Number: NL-OMON50982
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

* The patient is scheduled for primary unilateral TKA surgery in MUMC+ or St.
Anna Hospital;
* Diagnosis of OA;
* CPET can be performed three to six weeks before TKA surgery following the
preoperative screening;
* Mastery of the Dutch language.

Exclusion Criteria

* Undergoing revision arthroplasty, bilateral TKA or hemi-arthroplasty surgery;
* Contraindications for CPET according to the American Thoracic Society (ATS)
Statement on CPET and following the American Heart Association/American College
of Sports Medicine (AHA/ACSM) Health/Fitness facility preparticipation
screening questionnaire;
* Unable to get on and off a stationary bike;
* Complete dependence on a wheelchair;
* Serious comorbidities (e.g. malignancy, stroke);
* Cognitive impairments;
* Unable to sign informed consent.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Feasibility of CPET will be assessed against five criteria: 1) recruitment rate<br /><br>*20%; 2) CPET performance rate *90%; 3) *90% of participants reached the VAT;<br /><br>4) no serious adverse events; and 5) *80% of participants had a positive<br /><br>attitude towards CPET. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Aerobic capacity is determined by the VO2 at the VAT and the oxygen uptake<br /><br>efficiency slope (OUES). </p><br>