Evaluation of Ovarian Reserve Using Anti-müllerian Hormone and Antral Follicle Count in Ankylosing Spondylitis: Preliminary Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- anti-müllerian hormone (AMH)
Study Overview
Brief Summary
The aim of this study was to determine the status of ovarian reserve in patients with ankylosing spondylitis (AS) using anti-mullerian hormone (AMH) level and antral follicle count (AFC). Women with AS and women controls diagnosed according to the classification criteria proposed by the American-European Consensus Group will be included in the study. Ovarian reserve will be evaluated in terms of clinical findings, AFC and serum AMH and reproductive hormone levels.
Researchers predict that the ovarian reserve may be reduced in patients with AS due to the autoimmune process and the pathophysiology of the disease. Serum AMH and ovarian AFC may be useful for assessing ovarian reserve. It is aimed to determine the course of ovarian reserve abnormalities and the best possible biomarkers of reduced ovarian reserve in patients with AS.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •regular menstruation with intervals of 21-35 days;
- •cycle length variations <4 days;
- •both ovaries still present
Exclusion Criteria
- •history of liver failure;
- •diagnosed malignancy;
- •cigarette smoking;
- •chronic renal failure;
- •known infertility;
- •presence of gynecological abnormalities such as abnormal uterine bleeding or menorrhagia;
- •history of ovarian surgery;
- •history of hormone preparation (including corticosteroids) use or use of herbal products within 3 months;
- •diagnosis of polycystic ovary syndrome.
Outcomes
Primary Outcomes
anti-müllerian hormone (AMH)
Time Frame: 3 days
For ovarian capacity AMH will be examined and AMH levels will be recorded in pmol/l
antral follicle count (AFC)
Time Frame: 1 day
For ovarian capacity AFC will be examined and It will be recorded as a NUMBER.
Secondary Outcomes
No secondary outcomes reported
Investigators
Pınar Kadirogulları
Principal investigator, Pınar kadirogullari, M.D, Department of Obstetrics and Gynecology
Kanuni Sultan Suleyman Training and Research Hospital