Recovery of Ovarian Function and Reserve Parameters After Discontinuation of Long-term Use of Oral Contraception: Is the Recovery Period Related to AMH?
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Time for recovered menstrual cycle after discontinuation of oral contraception
研究概览
简要总结
The aim of this study is to investigate whether there is a correlation between anti-Müllerian hormone during long-term use of combined oral contraceptives and the recovery time before recovered menstrual cycle after discontinuation of oral contraceptives.
详细描述
Background:
Hormonal contraception is widely used among women worldwide; 50-89% of all women in the Western countries use oral contraception at some point in their lives. Oral contraceptives (OC) suppress the hypothalamic-pituitary-ovarian axis through a negative feedback of ethinyl estradiol and progestins and thereby potentially influence the markers of ovarian reserve due to a suppressed release of gonadotropins, which will impair the growth of antral follicles.
Methods and Materials:
Participants for this studies will be included through the Fertility Assessment and Counseling Clinic, Rigshospitalet, Herlev- and Hvidovre Hospital.
Inclusion criteria: Use of oral contraception (for study 3 at least during the last three years).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 26 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Minimum three years of oral contraceptives.
排除标准
- •Known infertility, known thyroid disease.
结局指标
主要结局
Time for recovered menstrual cycle after discontinuation of oral contraception
时间窗: 6 months after discontinuation
Ovarian reserve parameters before and after discontinuation of combined oral contraception
时间窗: 3 months after discontinuation
次要结局
- Correlation between suppression of the pituitary gonodal axis during use of oral contraceptives and time for recovered menstrual cycle(3 months)
研究者
Anders Nyboe Andersen
Professor M.D.
Rigshospitalet, Denmark